| Children |
| + | 1. Lucrezia de' Medici, b. 4 Aug 1470, Florence, Firenze, Tuscany, Italy  d. 15 Nov 1553 (Age 83 years) |
| | 2. unknown twin de' Medici, b. Mar 1471, Florence, Firenze, Tuscany, Italy d. Mar 1471, Florence, Firenze, Tuscany, Italy (Age ~ 0 years) |
| | 3. unknown twin de' Medici, b. Mar 1471, Florence, Firenze, Tuscany, Italy d. Mar 1471, Florence, Firenze, Tuscany, Italy (Age ~ 0 years) |
| | 4. Piero de' Medici, b. 15 Feb 1472, Florence, Firenze, Tuscany, Italy d. 28 Dec 1503 (Age 31 years) |
| | 5. Maddalena de' Medici, b. 25 Jul 1473 d. 2 Dec 1519 (Age 46 years) |
| | 6. Beatrice de' Medici, b. 23 Sep 1474, Florence, Firenze, Tuscany, Italy d. Sep 1474, Florence, Firenze, Tuscany, Italy |
| | 7. Giovanni de' Medici, b. 11 Dec 1475, Florence, Firenze, Tuscany, Italy d. 1 Dec 1521, Rome, Roma, Lazio, Italy (Age 45 years) |
| | 8. Luisa de' Medici, b. 1477, Florence, Firenze, Tuscany, Italy d. May 1488, Florence, Firenze, Tuscany, Italy (Age 11 years) |
| | 9. Antonia Romola de' Medici, b. 16 Jan 1478, Pistoia, Pistoia, Toscana, Italy d. 29 Jun 1515, Rome, Roma, Lazio, Italy (Age 37 years) |
| | 10. Giuliano de' Medici, b. 12 Mar 1479, Florence, Firenze, Tuscany, Italy d. 17 Mar 1516 (Age 37 years) |
|
1453 - 1488 (35 years)
