| Children |
| | 1. Eleonora de' Medici, b. 28 Feb 1567, Florence, Firenze, Tuscany, Italy  d. 9 Sep 1611, Cavriana, Mantova, Lombardia, Italy (Age 44 years) |
| | 2. Romola de' Medici, b. 20 Nov 1568, Florence, Firenze, Tuscany, Italy d. 2 Dec 1568, Florence, Firenze, Tuscany, Italy (Age 0 years) |
| | 3. Anna de' Medici, b. 31 Dec 1569, Florence, Firenze, Tuscany, Italy d. 19 Feb 1584, Florence, Firenze, Tuscany, Italy (Age 14 years) |
| | 4. Isabella de' Medici, b. 30 Sep 1571, Florence, Firenze, Tuscany, Italy d. 8 Aug 1572, Florence, Firenze, Tuscany, Italy (Age 0 years) |
| + | 5. Marie de' Medici, b. 26 Apr 1575, Palazzo Pitti, Florence, Tuscany, Italy d. 3 Jul 1642, Cologne, North Rhine-Westphalia, Germany (Age 67 years) |
| | 6. Lucrezia de' Medici, b. 7 Nov 1572, Florence, Firenze, Tuscany, Italy d. 14 Aug 1574, Florence, Firenze, Tuscany, Italy (Age 1 year) |
| | 7. Filippo de' Medici, b. 20 May 1577, Florence, Firenze, Tuscany, Italy d. 29 Mar 1582, Florence, Firenze, Tuscany, Italy (Age 4 years) |
|
1541 - 1587 (46 years)
