| Children |
| | 1. Infante Luis Fernando, b. 20 May 1849, Madrid, Madrid, Spain  d. 20 May 1849, Madrid, Madrid, Spain (Age 0 years) |
| | 2. Infante Fernando Francisco, b. 12 Jul 1850, Madrid, Madrid, Spain d. 12 Jul 1850, Madrid, Madrid, Spain (Age 0 years) |
| | 3. Infanta María Isabel, b. 20 Dec 1851, Royal Palace of Madrid, Madrid, Madrid, Spain d. 22 Apr 1931, Paris, Paris, Île-de-France, France (Age 79 years) |
| | 4. Infanta Maria Cristina, b. 5 Jan 1854, Madrid, Madrid, Spain d. 7 Jan 1854, Madrid, Madrid, Spain (Age 0 years) |
| | 5. Infanta Margarita, b. 23 Sep 1855, Madrid, Madrid, Spain d. 24 Sep 1855, Madrid, Madrid, Spain (Age 0 years) |
| | 6. Infante Francisco de Asis Fernando, b. 21 Dec 1856, Madrid, Madrid, Spain d. 21 Dec 1856, Madrid, Madrid, Spain (Age 0 years) |
| + | 7. Alfonso XII, King of Spain, b. 28 Nov 1857, Royal Palace of Madrid, Madrid, Madrid, Spain d. 25 Nov 1885, Royal Palace of El Pardo, Madrid, Madrid, Spain (Age 27 years) |
| | 8. Infanta Maria de la Conception, b. 1859, Madrid, Madrid, Spain d. 21 Oct 1861, Madrid, Madrid, Spain (Age 2 years) |
| | 9. Infanta María del Pilar of Spain, b. 4 Jun 1861, Madrid, Madrid, Spain d. 5 Aug 1879, Eskoriatza, Gipuzkoa, Pais Vasco, Spain (Age 18 years) |
| | 10. Infanta María de la Paz of Spain de Asís, b. 23 Jun 1862, Madrid, Madrid, Spain d. 4 Dec 1946, Nymphenburg Palace, Munich, München, Bavaria, Germany (Age 84 years) |
| | 11. Infanta Eulalia of Spain, b. 12 Feb 1864, Madrid, Madrid, Spain d. 8 Mar 1958, Irun, Gipuzkoa, Pais Vasco, Spain (Age 94 years) |
| | 12. Infante Francisco de Asis Leopoldo Maria Enrique, b. 24 Jan 1866, Madrid, Madrid, Spain d. 14 Feb 1866, Madrid, Madrid, Spain (Age 0 years) |
|
1822 - 1902 (79 years)
