| Children |
| | 1. Maria Isabel of Spain, b. 6 Sep 1740, Palace of Portici, Naples, Napoli, Campania, Italy  d. 2 Nov 1742 (Age 2 years) |
| | 2. Maria Josefa of Spain, b. 20 Jan 1742, Palace of Portici, Naples, Napoli, Campania, Italy d. 1 Apr 1742, Palace of Portici, Naples, Napoli, Campania, Italy (Age 0 years) |
| | 3. María Isabel Ana of Spain, b. 30 Apr 1743, Capodimonte, Napoli, Campania, Italy d. 5 Mar 1749 (Age 5 years) |
| | 4. María Josefa of Spain, b. 6 Jul 1744, Gaeta, Latina, Lazio, Italy d. 8 Dec 1801, Madrid, Madrid, Spain (Age 57 years) |
| | 5. Maria Luisa of Spain, b. 24 Nov 1745, Palace of Portici, Naples, Napoli, Campania, Italy d. 15 May 1792 (Age 46 years) |
| | 6. Felipe of Spain, b. 13 Jun 1747 d. 19 Sep 1777 (Age 30 years) |
| + | 7. Charles IV of Spain, King of Spain, b. 11 Nov 1748, Palace of Portici, Naples, Napoli, Campania, Italy d. 20 Jan 1819, Palazzo Barberini, Rome, Roma, Lazio, Italy (Age 70 years) |
| | 8. Maria Teresa of Spain, b. 2 Dec 1749 d. 2 May 1750, Palace of Portici, Naples, Napoli, Campania, Italy (Age 0 years) |
| | 9. Ferdinand I of the Two Sicilies, b. 12 Jan 1751, Naples, Napoli, Campania, Italy d. 4 Jan 1825 (Age 73 years) |
| | 10. Gabriel of Spain, b. 11 May 1752, Palace of Portici, Naples, Napoli, Campania, Italy d. 23 Nov 1788 (Age 36 years) |
| | 11. Maria Ana of Spain, b. 3 Jul 1754, Palace of Portici, Naples, Napoli, Campania, Italy d. 11 May 1755, Capodimonte, Napoli, Campania, Italy (Age 0 years) |
| | 12. Antonio Pascual of Spain, b. 31 Dec 1755 d. 20 Apr 1817 (Age 61 years) |
| | 13. Francisco Javier of Spain, b. 15 Feb 1757, Caserta, Caserta, Campania, Italy d. 10 Apr 1771, Royal Palace of Aranjuez, Aranjuez, Madrid, Madrid, Spain (Age 14 years) |
|
1716 - 1788 (72 years)
